Researchers from Aarhus University in Denmark have find a means to use antibodies to stop common allergic reactions from happening . This development could be life - changing for many people .
As report inNature Communications , the researchers have studied the human allergy antibody ( IgE ) and how it impound itself to cells . This is the gun trigger mechanism for the yield of histamine , which is the Southern Cross of supersensitized chemical reaction . The researchers looked at the biochemical mechanism that links the IgE to effector cellular telephone and discovered that a dissimilar antibody can instead take its station .
In laboratory test , the squad used the rip of patients sensitised to birch pollen and insect venom and pop out an supersensitised reaction while introducing the competitor antibody . It only took 15 minutes to disrupt the interaction between allergic reaction molecule and immune cells .
" Once the IgE on immune cells can be eliminated , it does n’t weigh that the soundbox produce billion of allergen - specific IgE molecule . When we can remove the trigger , the allergic reaction and symptoms will not come , " senior source Professor Edzard Spillner say in astatement .
The squad believes that this allergic reaction glide path can be apply to other types of allergy as well , not just pollen and insect spitefulness . Researchers reckon that 50 million people in the United States are affected bynasal allergy , and worldwide 250 million are affected by often deadly peanut allergic reaction .
“ We can now precisely map how the antibody forestall binding of IgE to its receptor . This allows us to picture totally novel strategy for engineering medicine of the future , " corresponding author Professor Nick Laursen added .
One of the interesting findings of the study is that the antibody is much small than the antibody presently used in allergy medicament .
" It is a so - call single domain antibody which is easily bring forth in physical process using only microorganisms . It is also extremely static , and this provides new opportunity for how the antibody can be mete out to patients , ” excuse co - writer Edzard Spillner .
The squad think the antibodies do n’t need to be injected but could be swallowed or inspire , which would make such therapy a lot easier for sufferers . It is still early days for this though . Clinical test will have to be behave to ensure that the approach is in effect and more significantly safe for humans .
