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A Modern COVID-19 oral contraceptive pill cuts the risk of hospitalization or death by 89 % when taken within three twenty-four hour period of symptom onset , Pfizer recently announced .
The antiviral pill , PAXLOVID , was give in a placebo - verify clinical trial to people with COVID-19 who were at eminent risk of develop severe disease . The pill ferment by suppress an enzyme called a proteolytic enzyme , which the virus SARS - CoV-2 needs to keep replicating .
The drug was so distinctly effective that an self-governing data point monitoring citizens committee urge the trial be stopped so that mass in the placebo - subdivision of the trial could meet the drug . Pfizer plans to put in the datum to the Food and Drug Administration ( FDA ) for emergency use authorization " as soon as potential , " according to a statement from the company .
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More than 1,200 adult in the U.S. and abroad who tested confident for SARS - CoV-2 and had mild to temperate symptom were enrolled in the clinical trial . Participants had at least one underlying consideration or characteristic that made them at high risk of developing severe disease . None of the participant were vaccinated , according to The New York Times . Each participant took either PAXLOVID , in combination with ritonavir ( an HIV drug that Pfizer says assist slow the partitioning of the antiviral drug , allowing it to stay in the body for longer ) , or a placebo lozenge every 12 hours for five day .
Out of 389 player who took PAXLOVID within three sidereal day of symptom oncoming , only three were hospitalized and none died , while out of 385 mass who took the placebo within three days , 37 were hospitalized and seven buy the farm .
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What ’s more , out of 607 participants who took PAXLOVID within five day of symptom onset ( include the people who make the drug within three days ) , six were hospitalise and none died . Out of 612 who took the placebo within five 24-hour interval of symptom onset , 41 were hospitalized and 10 decease . Adverse events were similar between the placebo and the data-based drug group and most were mild , according to the statement .
This is n’t the first COVID-19 pill to be developed ; The FDA is currently review Merck ’s COVID-19 pill , fuck as molnupiravir , which the company said cut COVID-19 hospitalizations and deaths by 50 % if taken within five days , and which was just approved in the United Kingdom , according to The Associated Press .
PAXLOVID is a modified version of a decade - old drug that was first developed as an endovenous cure during the SARS epidemic , but that now specifically targets SARS - CoV-2 and can be taken as a pill , according to the Times .
in the first place bring out on Live Science .
